- Local anesthetics reversibly block nerve transmission, when applied to a limited area of the body.
- They bind to the sodium channels in the nerve membrane and prevent the entry of sodium ions in response to the membrane’s depolarization.
- A vasoconstrictor like Adrenaline added to a local anaesthetic may significantly prolong the anaesthetic’s duration of action by reducing the blood flow around the injection site.
- This in turn may reduce the local anaesthetic’s peak plasma concentration and the risk of adverse systemic reactions.
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